Gold and Silver Staining: Techniques in Molecular Morphology

Gold and Silver Staining: Techniques in Molecular Morphology
Gerhard W. Hacker (Sous la direction de), Jiang Gu (Sous la direction de)

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Description du produit

Immunogold silver staining is one of the most sensitive techniques available for visualizing the location of antibodies and nucleotide probes that have been bounded to specific antigens or to nucleotide sequences. As gold and silver staining continues to advance research in molecular morphology, this book presents the information you need to know about the various staining methods, their useful applications, and the advantages and drawbacks of each process. Gold and Silver Staining: Techniques in Molecular Morphology provides a timely description of approaches, methods, protocols, and applications. The contributors cover the latest developments and a wide range of applications from highly sensitive detection of antigens to single copy detection of DNA and RNA. Some of the authors are "living legends" in the field and bring their expertise and experience to this fine collaboration. Written in one consistent style, each chapter includes a concise, but comprehensive introduction, step-by-step protocols with technical hints, and a discussion of results and critical steps. What differentiates this book from all others like it, is the status of the editors, who have worked on this technique from its inception and have produced innumerable publications on the topic. The other distinguishing feature is that all of the contributors are amongst the absolute foremost leaders from the United States and Europe. Gold and Silver Staining: Techniques in Molecular Morphology presents a complete overview and detailed descriptions of this technique that allows the visualization of molecules that have never been localized before and with hitherto unknown sensitivity. Not only does this book provide an excellent review of this field, but it also serves as a lab manual for those who want to carry out this technique in their laboratory and clinical work. Armed with this information, advances in this powerful field of research will ensue.

100 Challenges In Cardiology

100 Challenges In Cardiology
David R Ramsdale (Auteur), Simon Modi (Auteur)

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Hematopathology in Oncology

Hematopathology in Oncology
William G. Finn (Sous la direction de), LoAnn C. Peterson (Sous la direction de)

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Description du produit

Hematologist/oncologists rely heavily upon the discipline of hematopathology for the care and management of their patients. Whether interpreting a lymph node or bone marrow biopsy, directing a high throughput automated hematology laboratory, or translating testing modalities from the research bench to the clinical laboratory, hematopathologists and other laboratory medicine specialists provide a steady stream of critical data for the clinical practitioner. Recently the rapid advances in diagnosis and treatment of hematological disorders including the need to evaluate patients' eligibility for and monitor responses to rapidly evolving targeted therapies have made the close collaboration between pathologists and clinician practitioners even more essential. Our goal is to provide outstanding reviews of selected topics in hematopathology in a format that provides both general and historical background, as well as an overview of the state-of-the-art in diagnostic hematopathology, with an eye on future potential and future developments.

The Great Mortality: An Intimate History of the Black Death, the Most Devastating Plague of All Time

The Great Mortality: An Intimate History of the Black Death, the Most Devastating Plague of All Time
John Kelly (Auteur)

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Description du produit

“John Kelly gives the reader a ferocious, pictorial account of the horrific ravages of [The Black Death].” (Michiko Kakutani, New York Times )

“Splendidly written. Kelly has written a popular history based on the best scholarship available, and written it very well indeed.” (Detroit Free Press (**** 4 out of 4 stars) )

“A fascinating account of the plague. A frightening reminder of what could happen today.” (Nelson DeMille, The Birmingham News )

“Stunning. The Great Mortality [is endowed with] the sheer immediacy ancient history yields to only a few.” (Houston Chronicle )

“A compelling and bone-chilling account.” (Tampa Tribune )

“...splendidly written...” (Philadelphia Inquirer )

“This sweeping, viscerally exciting book contributes to a literature of perpetual fascination.” (Booklist (starred review) )

“A ground-level illustration of how the plague ravaged Europe…putting a vivid, human face on an unimaginable nightmare.” (Kirkus Reviews )

“...accessible and engrossing...” (Publishers Weekly )

“A compellingly vivid account.” (The Guardian )

“THE GREAT MORTALITY skillfully draws on eyewitness accounts to construct a journal of the plague years.” (New York Times Book Review )

“THE GREAT MORTALITY is a chilling account of a global siege, public pits, death-carts, silent villages and empty streets.” (Charleston Post & Courier )

“A compelling and eminently readable portrait.” (Library Journal )

“Powerful, rich, moving, humane, and full of important lessons for an age when weapons of mass destruction are loose.” (Richard Rhodes, Pulitzer Prize-winning author of The Making of the Atomic Bomb and John James Audubon: The Making of an American )

“Written with a keen eye for the details of the past, it might also be a warning about our future.” (Jack Weatherford, DeWitt Wallace Professor of Anthropology at Macalester College and author of Genghis Khan and the Making of the Modern World )

“Rich and evocative…written in the tradition of Barbara Tuchman, I couldn’t stop reading this work of brilliance and wisdom.” (Richard Preston, author of The Hot Zone )

Statistical Science in the Courtroom

Statistical Science in the Courtroom
Joseph L. Gastwirth (Auteur, Sous la direction de)

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Description du produit

Expert testimony relying on scientific and other specialized evidence has come under increased scrutiny by the legal system. A trilogy of recent U. S. Supreme Court cases has assigned judges the task of assessing the relevance and reliability of proposed expert testimony. In conjunction with the Federal judiciary, the American Association for the Advancement of Science has initiated a project to provide judges indicating a need with their own expert. This concern with the proper interpretation of scientific evidence, especially that of a proabilistic nature, has also occurred in England, Australia and in several European countries. Statistical Science in the Courtroom is a collection of articles written by statisticians and legal scholars who have been concerned with problems arising in the use of statistical evidence. A number of articles describe DNA evidence and the difficulties of properly calculating the probability that a random individual's profile would "match" that of the evidence as well as the proper way to intrepret the result. In addition to the technical issues, several authors tell about their experiences in court. A few have become disenchanted with their involvement and describe the events that led them to devote less time to this application. Other articles describe the role of statistical evidence in cases concerning discrimination against minorities, product liability, environmental regulation, the appropriateness and fairness of sentences and how being involved in legal statistics has raised interesting statistical problems requiring further research. The book should be of interest to students, lawyers, and judges with a modest quantitative background as well as statisticians, epidemiologists, geneticists and legal evidence scholars desiring a survey of the area. It informs potential experts about the legal process and introduces them to potential ethical issues they may face. Joseph L. Gastwirth is Professor of Statistics and Economics at George Washington University. He is a Fellow of the American Statistical Association and the Institute of Mathematical Statistics and was the recipient of a Guggenheim Fellowship to support his research on statistical problems arising in the legal setting. He is the author of Statistical Reasoning in Law and Public Policy and over one hundred articles in statistical methodology and its applications.

Palaeopathology

Palaeopathology
Tony Waldron (Auteur)

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Description du produit

"Researchers would want to use this text in the field, to introduce advanced undergraduates to the sub-discipline, and as a starting point for bridging anthropological and clinical data within their own research products." -PaleoAnthropology

"This very well written and comprehensive volume should prove useful to anyone attempting to diagnose disease from ancient human remains." -Douglas Ubelaker, Journal of Anthropological Research

Neuroanatomy: 3D-Stereoscopic Atlas of the Human Brain

Neuroanatomy: 3D-Stereoscopic Atlas of the Human Brain
Martin C. Hirsch (Auteur), Thomas Kramer (Auteur)
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Description du produit

The topographical and functional architecture of the human brain is highly complex. A profound understanding of this architecture is a prerequisite to understanding the functions and dysfunctions of the brain, to pass examinations in neuroanatomy, and to conduct operations in neurosurgery. The illustrations in this stereoscopic atlas have been developed with the greatest scientific thoroughness, and using an absolutely new 3D computer model. The use of a complex, stereoscopic visualization procedure presents the reader with a completely new and amazing, yet comprehensible, insight into the human brain. In combination with the CD-ROM, which contains all 175 illustrations as rotatable 3D models, this book introduces an innovative quality into the conception of spatial structures. It has never been so easy and fascinating to understand the architecture of the human brain!

Emerging Pathogens: The Archaeology, Ecology and Evolution of Infectious Disease

Emerging Pathogens: The Archaeology, Ecology and Evolution of Infectious Disease
Charles L. Greenblatt (Sous la direction de), Mark Spigel (Sous la direction de)

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Description du produit

... a fascinating book ... it succeeds quite well in bringing together a rather diverse set of approaches that are not often considered the business of 'mainstream' microbiology. It will appeal to final year microbiology undergraduates and postgraduates as well as senior researchers in bioarchaeology. (MicroBiology Today )

... provocative and informative. (The Lancet )

This is a very nicely produced book that contains much that is likely to be of interest to readers of the Transactions and the editors are to be congratulated on their initiative in producing a book that can truly be said to be original and for drawing so much disparate information together. (Transactions of the Royal Society of Tropical Medicine and Hygiene )

This publication is of importance for anybody with an interest in these pathogens. (European Journal of Protistology. )

Illustrated Textbook of Cardiovascular Pathology

Illustrated Textbook of Cardiovascular Pathology
FAMS. P Chopra MD FRCPath (Auteur)

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Handbook of Critical Care and Emergency Ultrasound

Handbook of Critical Care and Emergency Ultrasound
Christopher Moore (Auteur)

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